TRPML1 Inhibitor
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ML-SI3
0 ImagesSynonyms: ML-SI3 (cis/trans mix)ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 μM and 9.4 μM, respectively.
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(1R,2R)-ML-SI3
0 ImagesSynonyms: (-)-trans-ML-SI3
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(rel)-ML-SI3
0 ImagesSynonyms: trans-ML-SI3
